Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation
نویسندگان
چکیده
منابع مشابه
Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation
Eukaryotic protein kinases (EPKs) regulate numerous signaling processes by phosphorylating targeted substrates through the highly conserved catalytic domain. Our previous computational studies proposed a model stating that a properly assembled nonlinear motif termed the Regulatory (R) spine is essential for catalytic activity of EPKs. Here we define the required intramolecular interactions and ...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2013
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001680